achilles heel
Synonym discussion
Sense: noun/1
'Achilles heel' carries a strong sense of inevitability and consequence — it is not just a flaw but one that can cause complete failure when exploited. 'Weak spot' is the closest everyday alternative but lacks the dramatic implication of downfall ('His temper is a weak spot' vs. 'His temper is his achilles heel'). 'Vulnerability' is more technical and often used in cybersecurity or physical safety contexts; it describes the state of being exposed rather than a specific point. 'Soft underbelly' is informal and suggests the weak part is deliberately concealed but easily breached. 'Shortcoming' is a gentle, general term that implies a failure to meet a standard rather than a dangerous weakness. In a performance review you would say 'Her only shortcoming is impatience'; in a post-match analysis you would say 'The goalkeeper's slow reaction time proved to be the team's achilles heel.'
Etymology
From Greek mythology: the hero Achilles was dipped into the river Styx by his mother Thetis to make him invulnerable, but the heel by which she held him remained untouched by the water and was therefore his only weak point. He was eventually killed by an arrow to that heel. The metaphorical use of 'Achilles heel' to mean a critical weakness dates back to the 19th century.